Medication holiday — did you take a break? How did it go?

For anyone considering the switch from semaglutide to tirzepatide: I made that switch at month 6 and the difference in appetite suppression is noticeable. I went from thinking about food constantly (even on sema) to genuinely not being interested. The dual GIP/GLP-1 mechanism really does seem to add something.

My titration schedule ended up being much slower than the official guide. 0.25mg for 8 weeks, then 0.5mg for 8 more weeks. My doctor is conservative but the results have been steady and the side effects manageable. There's no prize for going faster.

Solidarity from someone who's been through the exact same thing. You've got this.

My doctor kept me at 0.5mg for 10 weeks. Slower titration, fewer side effects — worth it.